Karan Kapoor (Saif Ali Khan) works with one of India's leading newspapers as a cartoonist. He has cute cartoon characters, 'Hum' and 'Tum'.Karan meets Rhea (Rani Mukherjee) in an aircraft on his way to the U.S. They are complete opposites and are always at loggerheads with each other. Karan kisses her innocently after one of their arguments. Disaster strikes. End of a sweet budding friendship.Rhea and Karan continue to bump into each other at various phases of life and gradually become friends until they fall in love.
Rhea goes through a personal tragedy and Karan stands by her to offer her support. Karan even tries setting her up with his close friend, Mihir (Jimmy Shergil in a brief role), but nothing comes of this. Instead, Mihir gets engaged to Karan's friend Diana [Isha Koppikar].However, destiny has other plans for Karan and Rhea. This is what sets the film apart from the rest. Unlike in other films where the hero is frantically chasing the heroine or vice versa, here destiny is playing its games. Every time Rhea and Karan part ways you wonder if they will ever meet again. And they wouldn't, had it not been for destiny!

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